I14M (p.Ile14Met) variant of IL18R1 (Interleukin-18 receptor 1)
I14M (p.Ile14Met) in IL18R1 (Interleukin-18 receptor 1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data and structural context.
I14M (p.Ile14Met) variant details
- p.Ile14Met
- rs757943982
- ClinGen CA1809757
- ClinVar RCV004186219
- ExAC rs757943982
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.041
- REVEL 0.02
- CADD 0.05
- PolyPhen-2 0.00
- SIFT 0.74
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available