V14L (p.Val14Leu) variant of IL18 (Interleukin-18)
V14L (p.Val14Leu) in IL18 (Interleukin-18) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
V14L (p.Val14Leu) variant details
- p.Val14Leu
- TOPMed rs1354475224
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.05
- MetaLR 0.09
- MetaSVM -1.03
- CADD 8.40
- PolyPhen-2 0.24
- SIFT 0.19
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available