T22M (p.Thr22Met) variant of IL18 (Interleukin-18)
T22M (p.Thr22Met) in IL18 (Interleukin-18) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
T22M (p.Thr22Met) variant details
- p.Thr22Met
- cosmic curated COSV54781
- 1000Genomes rs61734549
- ESP rs61734549
- ExAC rs61734549
- Missense
- Variant Prioritization Score for Impact Estimate 0.275
- REVEL 0.07
- MetaLR 0.15
- MetaSVM -0.98
- CADD 20.80
- PolyPhen-2 0.77
- SIFT 0.12
- Most common in the HGDP:ADYGEI population (allele frequency 0.029)
- Structural context available