R80W (p.Arg80Trp) variant of IL18 (Interleukin-18)
R80W (p.Arg80Trp) in IL18 (Interleukin-18) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
R80W (p.Arg80Trp) variant details
- p.Arg80Trp
- TOPMed rs201058918
- gnomAD rs201058918
- Missense
- Variant Prioritization Score for Impact Estimate 0.204
- REVEL 0.08
- MetaLR 0.06
- MetaSVM -1.08
- CADD 22.20
- PolyPhen-2 0.67
- SIFT 0.19
- Most common in the Latino/Admixed American population (allele frequency 4.7e-05)
- Structural context available