R63W (p.Arg63Trp) variant of IL18 (Interleukin-18)
R63W (p.Arg63Trp) in IL18 (Interleukin-18) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
R63W (p.Arg63Trp) variant details
- p.Arg63Trp
- ESP rs199733090
- ExAC rs199733090
- TOPMed rs199733090
- gnomAD rs199733090
- Missense
- Variant Prioritization Score for Impact Estimate 0.175
- REVEL 0.16
- MetaLR 0.06
- MetaSVM -1.00
- CADD 14.10
- PolyPhen-2 0.41
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available