L56I (p.Leu56Ile) variant of IL18 (Interleukin-18)
L56I (p.Leu56Ile) in IL18 (Interleukin-18) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L56I (p.Leu56Ile) variant details
- p.Leu56Ile
- cosmic curated COSV54782
- gnomAD rs1182649992
- Missense
- Variant Prioritization Score for Impact Estimate 0.45
- REVEL 0.25
- MetaLR 0.43
- MetaSVM -0.07
- CADD 24.50
- PolyPhen-2 0.91
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available