F66S (p.Phe66Ser) variant of IL18 (Interleukin-18)
F66S (p.Phe66Ser) in IL18 (Interleukin-18) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
F66S (p.Phe66Ser) variant details
- p.Phe66Ser
- TOPMed rs1184810403
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.63
- REVEL 0.71
- MetaLR 0.42
- MetaSVM -0.13
- CADD 24.60
- PolyPhen-2 1.00
- SIFT 0.00
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available