V25M (p.Val25Met) variant of IL17RA (Interleukin-17 receptor A)
V25M (p.Val25Met) in IL17RA (Interleukin-17 receptor A) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
V25M (p.Val25Met) variant details
- p.Val25Met
- 1000Genomes rs1297016157
- TOPMed rs1297016157
- gnomAD rs1297016157
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.146
- REVEL 0.06
- MetaLR 0.02
- MetaSVM -0.96
- CADD 12.80
- PolyPhen-2 0.28
- SIFT 0.28
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available