S6T (p.Ser6Thr) variant of IL17RA (Interleukin-17 receptor A)
S6T (p.Ser6Thr) in IL17RA (Interleukin-17 receptor A) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
S6T (p.Ser6Thr) variant details
- p.Ser6Thr
- rs2061321130
- ClinGen CA410210090
- ClinVar RCV004315761
- Ensembl rs2061321130
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.109
- REVEL 0.01
- MetaLR 0.01
- MetaSVM -0.91
- CADD 3.05
- PolyPhen-2 0.01
- SIFT 0.77
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1e-06)
- Structural context available