P7A (p.Pro7Ala) variant of IL17RA (Interleukin-17 receptor A)
P7A (p.Pro7Ala) in IL17RA (Interleukin-17 receptor A) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
P7A (p.Pro7Ala) variant details
- p.Pro7Ala
- 1000Genomes rs534399492
- ExAC rs534399492
- TOPMed rs534399492
- gnomAD rs534399492
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.0668
- REVEL 0.02
- MetaLR 0.01
- MetaSVM -0.94
- CADD 0.01
- PolyPhen-2 0.01
- SIFT 1.00
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the East Asian population (allele frequency 3.6e-05)
- Structural context available