W112L (p.Trp112Leu) variant of IL12B (Interleukin-12 subunit beta)
W112L (p.Trp112Leu) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
W112L (p.Trp112Leu) variant details
- p.Trp112Leu
- Ensembl rs1562113473
- Missense
- Variant Prioritization Score for Impact Estimate 0.33
- REVEL 0.16
- MetaLR 0.05
- MetaSVM -1.05
- CADD 21.50
- PolyPhen-2 0.03
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available