T59I (p.Thr59Ile) variant of IL12B (Interleukin-12 subunit beta)
T59I (p.Thr59Ile) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
T59I (p.Thr59Ile) variant details
- p.Thr59Ile
- ExAC rs765124116
- gnomAD rs765124116
- Missense
- Variant Prioritization Score for Impact Estimate 0.174
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.08
- CADD 19.10
- PolyPhen-2 0.01
- SIFT 0.22
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available