T127P (p.Thr127Pro) variant of IL12B (Interleukin-12 subunit beta)
T127P (p.Thr127Pro) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
T127P (p.Thr127Pro) variant details
- p.Thr127Pro
- gnomAD 5-159322497-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.288
- REVEL 0.20
- MetaLR 0.11
- MetaSVM -1.00
- CADD 25.20
- PolyPhen-2 0.93
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available