S66R (p.Ser66Arg) variant of IL12B (Interleukin-12 subunit beta)
S66R (p.Ser66Arg) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
S66R (p.Ser66Arg) variant details
- p.Ser66Arg
- TOPMed rs1241195275
- gnomAD rs1241195275
- Missense
- Variant Prioritization Score for Impact Estimate 0.0856
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.01
- CADD 7.13
- PolyPhen-2 0.00
- SIFT 0.09
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available