S12P (p.Ser12Pro) variant of IL12B (Interleukin-12 subunit beta)
S12P (p.Ser12Pro) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
S12P (p.Ser12Pro) variant details
- p.Ser12Pro
- gnomAD rs1328015123
- Missense
- Variant Prioritization Score for Impact Estimate 0.264
- REVEL 0.22
- MetaLR 0.08
- MetaSVM -1.01
- CADD 23.30
- PolyPhen-2 0.60
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available