P42A (p.Pro42Ala) variant of IL12B (Interleukin-12 subunit beta)
P42A (p.Pro42Ala) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
P42A (p.Pro42Ala) variant details
- p.Pro42Ala
- TOPMed rs1754132622
- Missense
- Variant Prioritization Score for Impact Estimate 0.157
- REVEL 0.07
- MetaLR 0.03
- MetaSVM -1.03
- CADD 15.10
- PolyPhen-2 0.01
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available