L75V (p.Leu75Val) variant of IL12B (Interleukin-12 subunit beta)
L75V (p.Leu75Val) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
L75V (p.Leu75Val) variant details
- p.Leu75Val
- Ensembl rs1562113610
- Missense
- Variant Prioritization Score for Impact Estimate 0.374
- REVEL 0.24
- MetaLR 0.17
- MetaSVM -0.82
- CADD 20.40
- PolyPhen-2 0.38
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 5.4e-06)
- Structural context available