L35S (p.Leu35Ser) variant of IL12B (Interleukin-12 subunit beta)
L35S (p.Leu35Ser) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
L35S (p.Leu35Ser) variant details
- p.Leu35Ser
- TOPMed rs1469792164
- gnomAD rs1469792164
- Missense
- Variant Prioritization Score for Impact Estimate 0.228
- REVEL 0.04
- MetaLR 0.04
- MetaSVM -1.05
- CADD 23.00
- PolyPhen-2 0.06
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available