L26P (p.Leu26Pro) variant of IL12B (Interleukin-12 subunit beta)
L26P (p.Leu26Pro) in IL12B (Interleukin-12 subunit beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
L26P (p.Leu26Pro) variant details
- p.Leu26Pro
- rs754181875
- NCI-TCGA Cosmic COSV5145
- ExAC rs754181875
- gnomAD rs754181875
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.47
- REVEL 0.40
- MetaLR 0.18
- MetaSVM -0.75
- CADD 27.40
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available