L103P (p.Leu103Pro) variant of IL12B (Interleukin-12 subunit beta)
L103P (p.Leu103Pro) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
L103P (p.Leu103Pro) variant details
- p.Leu103Pro
- TOPMed rs1754123043
- Missense
- Variant Prioritization Score for Impact Estimate 0.555
- REVEL 0.58
- MetaLR 0.20
- MetaSVM -0.66
- CADD 25.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available