L103M (p.Leu103Met) variant of IL12B (Interleukin-12 subunit beta)
L103M (p.Leu103Met) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
L103M (p.Leu103Met) variant details
- p.Leu103Met
- TOPMed rs1217551438
- gnomAD rs1217551438
- Missense
- Variant Prioritization Score for Impact Estimate 0.324
- REVEL 0.33
- MetaLR 0.16
- MetaSVM -0.87
- CADD 23.00
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available