K134N (p.Lys134Asn) variant of IL12B (Interleukin-12 subunit beta)
K134N (p.Lys134Asn) in IL12B (Interleukin-12 subunit beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
K134N (p.Lys134Asn) variant details
- p.Lys134Asn
- NCI-TCGA Cosmic COSV5145
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.251
- REVEL 0.05
- MetaLR 0.04
- MetaSVM -1.06
- CADD 15.90
- PolyPhen-2 0.16
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available