I111V (p.Ile111Val) variant of IL12B (Interleukin-12 subunit beta)
I111V (p.Ile111Val) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
I111V (p.Ile111Val) variant details
- p.Ile111Val
- ExAC rs773815651
- gnomAD rs773815651
- Missense
- Variant Prioritization Score for Impact Estimate 0.0896
- REVEL 0.07
- MetaLR 0.04
- MetaSVM -0.95
- CADD 0.07
- PolyPhen-2 0.00
- SIFT 0.63
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available