G83E (p.Gly83Glu) variant of IL12B (Interleukin-12 subunit beta)
G83E (p.Gly83Glu) in IL12B (Interleukin-12 subunit beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
G83E (p.Gly83Glu) variant details
- p.Gly83Glu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.058
- REVEL 0.01
- MetaLR 0.02
- MetaSVM -0.98
- CADD 0.37
- PolyPhen-2 0.00
- SIFT 0.29
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available