D119G (p.Asp119Gly) variant of IL12B (Interleukin-12 subunit beta)
D119G (p.Asp119Gly) in IL12B (Interleukin-12 subunit beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
D119G (p.Asp119Gly) variant details
- p.Asp119Gly
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.168
- REVEL 0.04
- MetaLR 0.05
- MetaSVM -1.06
- CADD 23.50
- PolyPhen-2 0.33
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available