D115N (p.Asp115Asn) variant of IL12B (Interleukin-12 subunit beta)
D115N (p.Asp115Asn) in IL12B (Interleukin-12 subunit beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
D115N (p.Asp115Asn) variant details
- p.Asp115Asn
- NCI-TCGA Cosmic COSV5145
- Ensembl rs1754122054
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.362
- REVEL 0.13
- MetaLR 0.07
- MetaSVM -0.97
- CADD 24.00
- PolyPhen-2 0.48
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available