D109Y (p.Asp109Tyr) variant of IL12B (Interleukin-12 subunit beta)
D109Y (p.Asp109Tyr) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
D109Y (p.Asp109Tyr) variant details
- p.Asp109Tyr
- TOPMed rs1395936414
- gnomAD rs1395936414
- Missense
- Variant Prioritization Score for Impact Estimate 0.219
- REVEL 0.10
- AlphaMissense 0.08
- MetaLR 0.02
- MetaSVM -1.04
- CADD 20.70
- PolyPhen-2 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available