D109N (p.Asp109Asn) variant of IL12B (Interleukin-12 subunit beta)
D109N (p.Asp109Asn) in IL12B (Interleukin-12 subunit beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes structural context.
D109N (p.Asp109Asn) variant details
- p.Asp109Asn
- rs1395936414
- NCI-TCGA Cosmic COSV9918
- TOPMed rs1395936414
- gnomAD rs1395936414
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- AlphaMissense 0.08
- MetaLR 0.02
- MetaSVM -1.04
- PolyPhen-2 0.00
- SIFT 0.56
- EVE 0.11
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available