C131S (p.Cys131Ser) variant of IL12B (Interleukin-12 subunit beta)
C131S (p.Cys131Ser) in IL12B (Interleukin-12 subunit beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
C131S (p.Cys131Ser) variant details
- p.Cys131Ser
- gnomAD rs1235118140
- Missense
- Variant Prioritization Score for Impact Estimate 0.671
- REVEL 0.76
- MetaLR 0.50
- MetaSVM 0.07
- CADD 25.50
- PolyPhen-2 0.99
- SIFT 0.02
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available