W33R (p.Trp33Arg) variant of IL10RA (Q13651)
W33R (p.Trp33Arg) in IL10RA (Q13651) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
W33R (p.Trp33Arg) variant details
- p.Trp33Arg
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.396
- REVEL 0.40
- MetaLR 0.16
- MetaSVM -0.89
- CADD 22.80
- PolyPhen-2 0.09
- SIFT 0.26
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available