F34L (p.Phe34Leu) variant of IL10RA (Q13651)
F34L (p.Phe34Leu) in IL10RA (Q13651) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
F34L (p.Phe34Leu) variant details
- p.Phe34Leu
- NCI-TCGA Cosmic COSV9992
- 1000Genomes rs537603232
- ExAC rs537603232
- gnomAD rs537603232
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.63
- REVEL 0.68
- MetaLR 0.45
- MetaSVM -0.21
- CADD 27.60
- PolyPhen-2 0.97
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:GWD population (allele frequency 0.0043)
- Structural context available