T24S (p.Thr24Ser) variant of IL10 (Interleukin-10)
T24S (p.Thr24Ser) in IL10 (Interleukin-10) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Inflammatory bowel disease. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
T24S (p.Thr24Ser) variant details
- p.Thr24Ser
- rs1674877288
- ClinGen CA344482645
- ClinVar RCV001217119
- Ensembl rs1674877288
- Uncertain significance
- Inflammatory bowel disease
- Missense
- Variant Prioritization Score for Impact Estimate 0.157
- REVEL 0.04
- AlphaMissense 0.10
- MetaLR 0.10
- MetaSVM -0.96
- CADD 0.38
- PolyPhen-2 0.00
- ClinVar: Uncertain significance (Inflammatory bowel disease)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available