R42* (p.Arg42Ter) variant of IL10 (Interleukin-10)
R42* (p.Arg42Ter) in IL10 (Interleukin-10) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
R42* (p.Arg42Ter) variant details
- p.Arg42Ter
- rs1274280163
- NCI-TCGA Cosmic COSV6559
- gnomAD rs1274280163
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.542
- AlphaMissense 0.21
- MetaLR 0.42
- MetaSVM 0.01
- CADD 35.00
- PolyPhen-2 0.38
- SIFT 0.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available