P34T (p.Pro34Thr) variant of IL10 (Interleukin-10)
P34T (p.Pro34Thr) in IL10 (Interleukin-10) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Inflammatory bowel disease; not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
P34T (p.Pro34Thr) variant details
- p.Pro34Thr
- rs2102441015
- ClinGen CA344482577
- ClinVar RCV001359362
- ClinVar RCV004728667
- Uncertain significance
- Inflammatory bowel disease; not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.214
- REVEL 0.14
- CADD 15.50
- PolyPhen-2 0.21
- SIFT 0.03
- ClinVar: Uncertain significance (Inflammatory bowel disease; not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.3e-05)
- Structural context available