N63S (p.Asn63Ser) variant of IL10 (Interleukin-10)
N63S (p.Asn63Ser) in IL10 (Interleukin-10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
N63S (p.Asn63Ser) variant details
- p.Asn63Ser
- rs776711200
- NCI-TCGA Cosmic COSV6559
- ExAC rs776711200
- gnomAD rs776711200
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.116
- REVEL 0.15
- CADD 0.56
- PolyPhen-2 0.00
- SIFT 0.76
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available