L71M (p.Leu71Met) variant of IL10 (Interleukin-10)
L71M (p.Leu71Met) in IL10 (Interleukin-10) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
L71M (p.Leu71Met) variant details
- p.Leu71Met
- 1000Genomes rs200783164
- ESP rs200783164
- ExAC rs200783164
- TOPMed rs200783164
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.43
- REVEL 0.47
- CADD 24.90
- PolyPhen-2 1.00
- SIFT 0.02
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the HGDP:MOZABITE population (allele frequency 0.02)
- Structural context available