H32Y (p.His32Tyr) variant of IL10 (Interleukin-10)
H32Y (p.His32Tyr) in IL10 (Interleukin-10) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
H32Y (p.His32Tyr) variant details
- p.His32Tyr
- ESP rs376787667
- ExAC rs376787667
- TOPMed rs376787667
- gnomAD rs376787667
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.167
- REVEL 0.07
- CADD 15.00
- PolyPhen-2 0.00
- SIFT 0.19
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available