G21D (p.Gly21Asp) variant of IL10 (Interleukin-10)
G21D (p.Gly21Asp) in IL10 (Interleukin-10) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Inflammatory bowel disease. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data and structural context.
G21D (p.Gly21Asp) variant details
- p.Gly21Asp
- rs766916310
- ClinGen CA36550837
- ClinVar RCV002585646
- TOPMed rs766916310
- Uncertain significance
- Inflammatory bowel disease
- Missense
- Variant Prioritization Score for Impact Estimate 0.0398
- REVEL 0.02
- CADD 1.15
- PolyPhen-2 0.01
- SIFT 0.42
- ClinVar: Uncertain significance (Inflammatory bowel disease)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available