S10F (p.Ser10Phe) variant of IKZF1 (DNA-binding protein Ikaros)
S10F (p.Ser10Phe) in IKZF1 (DNA-binding protein Ikaros) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
S10F (p.Ser10Phe) variant details
- p.Ser10Phe
- NCI-TCGA Cosmic COSV5878
- cosmic curated COSV58782
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.369
- REVEL 0.18
- CADD 22.30
- PolyPhen-2 0.08
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available