G6S (p.Gly6Ser) variant of IKZF1 (DNA-binding protein Ikaros)
G6S (p.Gly6Ser) in IKZF1 (DNA-binding protein Ikaros) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
G6S (p.Gly6Ser) variant details
- p.Gly6Ser
- TOPMed rs1024766283
- Missense
- Variant Prioritization Score for Impact Estimate 0.115
- REVEL 0.07
- CADD 16.10
- PolyPhen-2 0.02
- SIFT 0.19
- Most common in the African/African-American population (allele frequency 6e-05)
- Structural context available