G25A (p.Gly25Ala) variant of IKBKB (O14920)
G25A (p.Gly25Ala) in IKBKB (O14920) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, published literature, and structural context.
G25A (p.Gly25Ala) variant details
- p.Gly25Ala
- gnomAD 8-42272174-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.359
- REVEL 0.19
- MetaLR 0.13
- MetaSVM -0.95
- CADD 25.10
- PolyPhen-2 0.53
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available
- Literature evidence available