A21E (p.Ala21Glu) variant of IFNGR2 (Interferon gamma receptor 2)
A21E (p.Ala21Glu) in IFNGR2 (Interferon gamma receptor 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
A21E (p.Ala21Glu) variant details
- p.Ala21Glu
- 1000Genomes rs1445046014
- TOPMed rs1445046014
- gnomAD rs1445046014
- Missense
- Variant Prioritization Score for Impact Estimate 0.341
- REVEL 0.13
- MetaLR 0.13
- MetaSVM -0.94
- CADD 18.20
- PolyPhen-2 0.49
- SIFT 0.42
- Most common in the Non-Finnish European population (allele frequency 3e-05)
- Structural context available