V45L (p.Val45Leu) variant of IFNG (Interferon gamma)
V45L (p.Val45Leu) in IFNG (Interferon gamma) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
V45L (p.Val45Leu) variant details
- p.Val45Leu
- gnomAD rs1461185598
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- REVEL 0.27
- MetaLR 0.21
- MetaSVM -0.79
- CADD 19.00
- PolyPhen-2 0.49
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 2.5e-05)
- Structural context available