V15I (p.Val15Ile) variant of IFNG (Interferon gamma)
V15I (p.Val15Ile) in IFNG (Interferon gamma) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
V15I (p.Val15Ile) variant details
- p.Val15Ile
- rs757239347
- NCI-TCGA Cosmic COSV5749
- ExAC rs757239347
- TOPMed rs757239347
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.063
- REVEL 0.01
- MetaLR 0.02
- MetaSVM -0.97
- CADD 0.19
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available