T4A (p.Thr4Ala) variant of IFNG (Interferon gamma)
T4A (p.Thr4Ala) in IFNG (Interferon gamma) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
T4A (p.Thr4Ala) variant details
- p.Thr4Ala
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.117
- REVEL 0.06
- MetaLR 0.07
- MetaSVM -0.99
- CADD 11.90
- PolyPhen-2 0.14
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 2.4e-05)
- Structural context available