G20S (p.Gly20Ser) variant of IFNG (Interferon gamma)
G20S (p.Gly20Ser) in IFNG (Interferon gamma) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
G20S (p.Gly20Ser) variant details
- p.Gly20Ser
- NCI-TCGA Cosmic COSV5749
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0995
- REVEL 0.07
- MetaLR 0.07
- MetaSVM -1.05
- CADD 0.20
- PolyPhen-2 0.03
- SIFT 0.91
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available