A40S (p.Ala40Ser) variant of IFNG (Interferon gamma)
A40S (p.Ala40Ser) in IFNG (Interferon gamma) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, published literature, and structural context.
A40S (p.Ala40Ser) variant details
- p.Ala40Ser
- gnomAD 12-68158256-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.228
- REVEL 0.08
- MetaLR 0.12
- MetaSVM -0.98
- CADD 16.10
- PolyPhen-2 0.45
- SIFT 0.29
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available
- Literature evidence available