I9M (p.Ile9Met) variant of IFNAR2 (Interferon alpha/beta receptor 2)
I9M (p.Ile9Met) in IFNAR2 (Interferon alpha/beta receptor 2) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided; not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
I9M (p.Ile9Met) variant details
- p.Ile9Met
- rs750264158
- ClinGen CA10005495
- ClinVar RCV001982607
- ClinVar RCV004043698
- Uncertain significance
- not provided; not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0619
- REVEL 0.06
- CADD 1.42
- PolyPhen-2 0.12
- SIFT 0.05
- ClinVar: Uncertain significance (not provided; not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available