S22F (p.Ser22Phe) variant of IFNAR1 (Interferon alpha/beta receptor 1)
S22F (p.Ser22Phe) in IFNAR1 (Interferon alpha/beta receptor 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
S22F (p.Ser22Phe) variant details
- p.Ser22Phe
- ExAC rs745384435
- gnomAD rs745384435
- Missense
- Variant Prioritization Score for Impact Estimate 0.362
- REVEL 0.12
- MetaLR 0.24
- MetaSVM -0.86
- CADD 21.60
- PolyPhen-2 0.06
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available