L5F (p.Leu5Phe) variant of IFNAR1 (Interferon alpha/beta receptor 1)
L5F (p.Leu5Phe) in IFNAR1 (Interferon alpha/beta receptor 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
L5F (p.Leu5Phe) variant details
- p.Leu5Phe
- gnomAD 21-33325068-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.118
- REVEL 0.04
- MetaLR 0.20
- MetaSVM -0.93
- CADD 11.30
- PolyPhen-2 0.07
- SIFT 0.24
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available